How ViziLite^® Plus with TBlue^® Works

When cells mutate from normal to becoming cancerous they go through many changes. One change that occurs within the cell is the replication of nuclear DNA at an accelerated rate. The DNA takes up a greater percentage of the total cell volume as shown in the illustration below. The ratio between the nucleus and the cytoplasm can increase until the nucleus takes up nearly 100% of the cell volume.

With ViziLite® Plus with TBlue®, oral healthcare professionals now have a diagnostic aid that helps them identify, evaluate, monitor and mark abnormal oral lesions that may be going through these dysplastic changes. The pre-rinse solution in ViziLite® Plus with TBlue® slightly desiccates the cells to make the nuclei more prominent, and, therefore, more visible. The low intensity light from the handheld light source is reflected off of these abnormal cells down to the basement membrane where the nuclei have been rendered more prominent, and appear to "glow" – making abnormal cells easier to see.

TBlue®

TBlue® is a toluidine blue-based metachromatic dye used to mark ViziLite® identified lesions for further evaluation and monitoring for changes. TBlue®, packaged in an easy-to-use three-swab system, provides the deep blue staining that allows ViziLite®-identified lesions to be seen clearly under normal light.⁵